Distress During Pregnancy: Epigenetic Regulation of Placenta Glucocorticoid-Related Genes and Fetal Neurobehavior
نویسندگان
چکیده
منابع مشابه
Distress During Pregnancy: Epigenetic Regulation of Placenta Glucocorticoid-Related Genes and Fetal Neurobehavior.
OBJECTIVE Increased risk of psychopathology is observed in children exposed to maternal prenatal distress, and elevated maternal cortisol and epigenetic regulation of placental glucocorticoid-pathway genes are potential mechanisms. The authors examined maternal distress and salivary cortisol in relation to fetal movement and heart rate ("coupling") and DNA methylation of three glucocorticoid pa...
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OBJECTIVE This was a prospective study of the effects of maternal smoking during pregnancy on newborn neurobehavior, including dose-response relationships using self-report and a bioassay of nicotine exposure. METHODS The sample included 27 nicotine exposed and 29 unexposed full-term newborn infants with no medical problems from comparable social class backgrounds. Mothers were excluded for u...
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Introduction: Fasting is a commitment to God, therefore many pregnant women have a tendency to perform it, but they are concerns about its possible complications which may affect fetal health. Objective: This study aimed to determine the relationship between fasting on pregnant women and their fetal birth weight. Method: This study was conducted on pregnant women referring to maternity hospital...
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Introduction: Lansoprazole is one of the proton pump inhibitor drugs widely used in the treatment of gastro-duodenal ulcers and disorders. However, there is not enough data about unexplored adverse effects of lansoprazole on the integrity of the placental barrier. Therefore, the present study was conducted to determine whether placental structure could be affected by lansoprazole administrati...
متن کاملO-37: Pseudomalignant Nature of Placenta during Normal and Pathological Gestation Is Regulated by Epigenetic Mechanisms which Can be Exploited To Design Non-Invasive Fetal Dna Markers
Background Placentation shares many analogues with the development of tumors such as rapid proliferation, invasiveness, gene expression profiles especially the expression of tumor suppressor genes, oncogenes and matrixmetallo proteinases (MMPs). Thus, a placenta has been described as a pseudomalignant tissue. However, placentation is tightly regulated and any deregulation of this pseudomalignan...
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ژورنال
عنوان ژورنال: American Journal of Psychiatry
سال: 2016
ISSN: 0002-953X,1535-7228
DOI: 10.1176/appi.ajp.2015.15091171